منابع مشابه
The development of the vertebrate inner ear
The inner ear is a complex sensory organ responsible for balance and sound detection in vertebrates. It originates from a transient embryonic structure, the otic vesicle, that contains all of the information to develop autonomously into the mature inner ear. We review here the development of the otic vesicle, bringing together classical embryological experiments and recent genetic and molecular...
متن کاملSp8 regulates inner ear development.
A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has identified an inner ear mutant named eclipse (ecl). Mutants developed enlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular and inverted swimming patterns. Positional cloning identified specificity protein 8 (sp8), which was previously found to regulate limb and ...
متن کاملMolecular mechanisms of inner ear development.
The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a relatively common consequence of human genetic mutation. Studies in model organisms suggest that many genes currently known to be associated with human hearing impairment are active during embryogenesis. Henc...
متن کاملthe impact of morphological awareness on the vocabulary development of the iranian efl students
this study investigated the impact of explicit instruction of morphemic analysis and synthesis on the vocabulary development of the students. the participants were 90 junior high school students divided into two experimental groups and one control group. morphological awareness techniques (analysis/synthesis) and conventional techniques were used to teach vocabulary in the experimental groups a...
15 صفحه اولRole of microRNA-18a in the development of inner ear
Objective: The developmental process of vertebrate inner ear is complex. MicroRNAs (miRNAs) have been reported to be involved in the development of inner ear. The current study was designed to explore the potential role of miR-18a in the development of inner ear. Methods: The expression of miR-18a and lysine demethylase 5B (Kd5mb) in inner ear tissues and house Ear Institute-Organ of Corti 1 (H...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2015
ISSN: 0959-437X
DOI: 10.1016/j.gde.2015.02.006